Here's a neat transcript of a talk by Mat Marquis where he details how he made the Bocoup website lightning fast, particularly with snazzy font loading tricks and performance tools to help monitor those improvements over time.
Although, my favorite part of the talk is when Mat goes into why he wants to make websites:
I don't get excited about frameworks or languages—I get excited about potential; about playing my part in building a more inclusive web.
I care about making something that works well for someone that has only ever known the web by way of a five-year-old Android device, because that's what they have—someone who might feel like they're being left behind by the web a little more every day. I want to build something better for them.