Ask a bunch of designers what they wish CSS could do that it can't now, and you'll get a big list that reads much like the list of features for the Compass/Sass framework. If you are like me, you don't have any trouble writing CSS, but the thought of being able to using things like variables, mixins, and nesting is rather enticing. I learned quite a bit in my first musings with Compass/Sass and answered a lot of my own questions about how it works. You'll see it all here.
Links from the video: