This is not a "framework" or anything, I was just screwing around with typography and getting things to line up according to a strict horizontal and vertical grid. It is inspired by the Compose to a Vertical Rhythm article by Richard Rutter a few years ago, except uses unitless line height.
font: 10px/2 "Lucida Grande", Helvetica, Sans-Serif;
I thought the results were very pleasing. If you have a site heavy on text content, I think paying fine-grained attention to the underlying grid is important.