Nice article. Thanks for the link. I have partly been doing this in all of my recent dev. More just making targets bigger and not so much thinking about placement based on the way a device is held. We can’t really know what way the device will be held tho just by knowing size and if it is touch or not.
Still the ‘coarse’ css’4′ addition is kinda cool. Perhaps it might turn into even having a simple way for the user to decide if they want the site to be optimized for the 2 thumb sides or one of the other configurations shown. Much like the old ‘view desktop mode’.
But rather an adaptive layout the user can choose from or toggle between because they might like one in landscape better than portrait or vice versa