You’re right @jdleblanc – it just depends on what your portfolio is of. If it’s there to display your web design skills, you may not want to use a side-scrolling layout. Illustrations, photography, and images of work all seem appropriate.
A layout like the one I linked to is easy enough to accomplish in an hour. Do you need any help? The most obvious way you could implement CSS3 would be to use a box-shadow on your images.