There are a ton of options out there for font replacement, including various great WordPress plugins that make font substitute easier than ever. All of the plugins included are compatible up to WP 3.1.4, and most are compatible up to 3.2.1.
TYPEKIT FONTS FOR WORDPRESS
WP WEB FONTS
WP GOOGLE FONTS
Webfont performance is sure to grow in the immediate future, due to the options it opens up for designers, and there are sure to be more font replacement plugins available in the coming months and years.